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Neurochemical Effects Research indicates that GLP-1 agonists might affect dopamine levels in the brain

For example, the largest STEP trial published to date reported that GI issues affected 74.2% of volunteers taking semaglutide, as opposed to 47.9% taking placebo

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J Am Coll Cardiol 2020

Up-regulation of glutamate receptors is associated with LTP defects in the early stages of diabetes mellitus

Whilst the fundamental pharmacology remains unchanged, strategic timing and dose management may improve tolerability