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Immediate triggers are often indirect, including low blood sugar, dehydration, and anxiety, and clinical trials observed increased heart rate in roughly 2 out of 100 patients, which supports investigating reversible causes first

Step therapy is a requirement that you have tried and failed at least one lower-cost FDA-approved medication for your condition

This led to semaglutide being recommended for diabetics with cardiovascular disease, even before it was widely marketed, and it solidified the idea that GLP-1 RAs have a class benefit on the heart

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