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Annals of Internal Medicine DOI:10.7326/ANNALS-25-00860 Abstract Glucagon-Like Peptide-1 Receptor Agonists and Risk for Ischemic Optic Neuropathy: A Target Trial Emulation Background: There are few data evaluating the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and nonarteritic anterior ischemic optic neuropathy (NAION), which constitutes approximately 75% of ischemic optic neuropathy (ION) cases in adults

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In contrast, Wegovy targets only the GLP-1 receptor, which still provides substantial weight loss benefits but generally at a lower magnitude