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Implications for Development Phase 1 results informed dose selection for Phase 2 trials, identifying optimal dosing ranges that balanced efficacy with tolerability

OCT3, another member of the solute carrier family 22 (SCL22), is instead mainly expressed in the skeletal muscle but is also expressed in the intestine, and it is associated with metformin efflux in the salivary glands, leading to dysgeusia during metformin treatment [191]

J Cachexia Sarcopenia Muscle 13(2):919931 Lim C, Nunes EA, Currier BS, Mcleod JC, Thomas AC, Phillips SM (2022) an evidence-based narrative review of mechanisms of resistance exerciseinduced human skeletal muscle hypertrophy

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This medication can affect gastric emptying and potentially increase risks during anesthesia

Results vary from person to person, as everyone responds to medication differently