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Each interruption triggers appetite rebound and weight regain, requiring re-adjustment and often higher doses to restart

At present, several GLP-1 analogs have joined the class, such as exenatide, liraglutide, dulaglutide, semaglutide and tirzepatide [1]

Based on collective human data, a glycemic threshold of 99 108 mg/dL may exist, below which GIP primarily exerts glucagonotropic actions (35)

A related formulation, Wegovy (also semaglutide), has been approved separately for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with weight-related comorbidities, and is prescribed through specialist weight management services

Carolynn Francavilla, an obesity medicine physician and vice president of the Obesity Medicine Association

Whatever the reason, changing your injection day is straightforward if you follow the rules