mechanism of glp 1 receptor agonist Frontiers Mechanism of action of GLP-1

*FOR ORAL SEMAGLUTIDE USED FOR TYPE 2 DIABETES SOURCE: American Diabetes Association

Effects of Semaglutide With and Without Concomitant SGLT2 Inhibitor Use in Participants With Type 2 Diabetes and Chronic Kidney Disease in the FLOW Trial

At full therapeutic doses, roughly 40% of patients experience GI side effects severe enough to consider stopping

Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, pla-cebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise

Available from: 10 Goldman Sachs, 2023

Because allulose is only present in small amounts in a few foods, it is typically prepared commercially