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New targets for drug treatment of obesity

Masson, A

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Slower Movement Does Not Mean Simpler Operations There is a counterintuitive dynamic at work here that can be easy to miss

Quick Answer: Why GLP-1 Causes Gut Issues GLP-1 medications mimic a natural hormone that helps regulate blood sugar and appetite

in particular, one study reported the mechanism by which nucleus-tractus-solitarius-derived GLP-1 modulates neuronal activity and food intake behavior (through the following steps: GLP-1R signaling stimulates the PKA signaling pathway, which promotes phosphorylation of GluA1 S845, increasing GluA1 membrane trafficking and postsynaptic excitatory synaptic transmission), whereas alterations in the paraventricular nucleus of the hypothalamus GLP-1 signaling induced obesity [37]