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Testing methods and reference standards must be appropriate for the manufacturing route methods validated against Novo Nordisks recombinant reference standard may miss synthesis-related impurities in compounded products

compounding pharmacies were compounding-only

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Evaluation of the remodeling capacity of the extracellular matrix promoted by the pancreatic MMP-2 (matrix metalloproteinase-2) revealed that treatments with the QV formulation or insulin reduced the MMP-2 activity in relation to the untreated diabetic group, and at levels similar to the control group (Fig