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Diabetes Care 2012;35:252258

Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

DSC and HSM confirmed that SMG remains amorphous under all tested conditions and revealed three major thermal events: residual water loss, enthalpy recovery associated with physical ageing, and thermal decomposition

Expect 15-20% weight loss rather than full 24%

However, heavy or frequent alcohol use can reduce the effectiveness of the medication and increase the risk of side effects

This, along with eating less overall, can sometimes lead to fewer bowel movements and constipation. Often, the constipation caused by semaglutide drugs like Ozempic is mild and temporary