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Psychiatric Effects of GLP-1 Receptor Agonists: A Systematic Review of Emerging Evidence

Abstract Human GLP-1 (glucagon-like peptide-1) can produce a remarkable improvement in glycemic control in patients with type 2 diabetes

The basolateral amygdala (BLA), a critical component of the amygdala within the brains limbic system, plays a central role in emotion processing, memory formation, and fear conditioning [9,10]

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A portion of the GLP-1 receptors in neurons are located in the nucleus of the solitary tract (NTS), which is functionally connected to the hypothalamus and hindbrain, and the GLP-1 generated in the NTS works by binding to the receptors in the plasma membrane of the neurons directly involved in appetite control (34)