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Systematic evaluation of glucose control, body mass index, blood pressure, insulin secretion and insulin resistance is leveraged to identify patients who are likely to receive the greatest metabolic benefit from common antidiabetic drugs.

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In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

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