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Lilly announced the topline results from its phase 3b "TOGETHER PsA" trial, showing that the combination use of ixekizumab (Taltz) and tirzepatide (Zepbound) was superior to IXE alone, yielding both significant weight loss and ACR50 disease control in adults with active psoriatic arthritis (PsA).

Both drugs affect appetite and metabolism through different pathways, creating potential safety concerns and interaction risks that should be addressed with a qualified healthcare provider

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Understanding refrigeration requirements, pre-filled pen handling, and storage after first use is critical for medication stability and safety

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Why Muscle Loss Is the Real Challenge for GLP-1 Users GLP-1 medications work by reducing appetite and slowing digestion, which leads to a significant calorie deficit over time