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2 Several factors contribute to this: AEDs such as sodium valproate, carbamazepine, gabapentin, and pregabalin are associated with weight gain Seizure-related fatigue and activity restrictions can reduce physical activity levels Some people with epilepsy experience changes in appetite regulation Obesity itself has been associated with a 2.3-fold increased risk of drug-resistant epilepsy 3 This creates a cycle where AEDs contribute to weight gain, and excess weight may worsen seizure control