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The mechanisms underlying taste perception changes during GLP-1 therapy are likely multifactorial and indirect rather than representing true gustatory dysfunction

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Several clinical trials have also shown that GLP-1s can reduce an inflammation marker in the bloodbut its still unclear how much of that improvement is the result of weight loss or an independent effect of the drugs

This could diminish the unique advantage retatrutide holds over dual-agonists like tirzepatide

Food and Drug Administration (FDA) are generally considered safe and effective

FDA-approved medications have extensive clinical trial data