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While lifestyle interventions are the cornerstone of obesity prevention and management, they often fail to result in sustained and meaningful weight loss (WL)

Our findings suggest that the GLP-1R-independent effects of GLP-1 may involve the activation of GCGRs

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Moreover, studies by Pal et al

Newer options include roflumilast (Daliresp), which works by blocking the release of immune system proteins called cytokines to reduce itch and inflammation, and tapinarof (Vtama), which regulates the skin's immune responses and supports building and maintaining the skin barrier

Exendin-4 alleviates retinal vascular leakage by protecting the blood-retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats