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The gastric slowing effect is modest, and appetite suppression is mild

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Sustained Weight Reduction With Once-Weekly Semaglutide: Results From a Real-World Retrospective Cohort Study in the United States (Scope 24 Months)

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SURMOUNT-3 was a multi-centre, randomised, double-blind, parallel, placebo-controlled trial comparing the efficacy and safety of tirzepatide to placebo for 72 weeks after a 12-week intensive lifestyle intervention lead-in period in adults with obesity or overweight with weight-related comorbidities, excluding type 2 diabetes

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A study published in JAMA Internal Medicine contrasting the effects of taking semaglutide and tirzepatideconsisting of both a GLP-1 receptor agonist and a gastric inhibitory polypeptideon patients with type 2 diabetes showed that tirzepatide has a greater impact on weight loss than semaglutide

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