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For example, GLP-1 enhances L-type Ca 2+ currents through activation of the cAMP-dependent PKA pathway in canine cardiomyocytes [71], whereas when rat hippocampal neurons are pre-incubated with GLP-1 for 24 h, Ca 2+ currents are significantly decreased [58]

An observational study published in 2023 in Diabetes Care that looked to determine whether the use of GLP-1 medications was associated with an increased risk of thyroid cancer found that in 1-3 years of treatment, the risk for thyroid cancer was increased for those taking GLP-1 medications (2)
21 For example, in dietinduced obese mice, use of a novel GIP analogue enhanced GLP-1RA-induced body weight loss and improved glycemic control secondary to suppression of food intake

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