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22 Patients in subtype A have active proliferation of epithelial cells, significant enrichment of associated signaling pathways such as the Wnt/-catenin pathway, and relatively strong repair and regeneration of epithelial cells

Yassine HN, Solomon V, Thakral A, Sheikh-Bahaei N, Chui HC, Braskie MN, Schneider LS, Talbot K (2022) Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists

Glucagon-like peptide-1 (GLP-1) receptor agonist and dual agonist therapies are FDA-approved for the treatment of obesity, weight management, type 2 diabetes mellitus and cardiovascular mortality reduction

Because PlexusDx medications are HSA and FSA eligible, you can direct pre-tax healthcare dollars toward your weight-management plan immediately

- For clinicians/POs: Pay attention to adiposecompartment outcomes (visceral vs subcutaneous) and functional endpoints beyond weight

Overall, the benefit-risk profile supports broad use of GLP-1-based therapies in MASLD across most patient subgroups, with individualized monitoring plans for high-risk populations