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Furthermore, escalated relapse drinking after repeated withdrawal phases is attenuated by another GLP-1R agonist, AC3174 (Suchankova et al., 2015)

For pure weight loss, retatrutide leads the data

This could lead to unpredictable reactions beyond just skin issues

However, he added that, in his opinion, a study comparing semaglutide with other meds to treat diabetes and heart failure would be helpful. Wright noted that [i]t now seems likely that cornerstone therapy for type 2 diabetic patients with obesity should be coadministration of an SGLT2 inhibitor and a GLP-1 receptor agonist, instead of the historic and perhaps now somewhat obsolete treatment with metformin and insulin. Whether their optimism is justified remains to be seen, but this study suggests that semaglutide could be an effective treatment for heart failure associated with diabetes.

News articles abound about the fears around high prices for GLP-1s, and Senators are claiming the prices are unjustifiably high because of how many patients could benefit from them if they were cheaper

Baseline assessment helps set realistic timelines and goals
