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5f, g, Supplementary Table 4)

Lancet 2021;397:97184.ArticlePubMed 48

Continued tirzepatide therapy sustained and even augmented initial weight loss, whereas discontinuation resulted in marked weight regain, confirming its durable effectiveness and good tolerability for long-term weight management (31)

Preclinical data demonstrate that GLP-1 and GLP-1RAs exert anti-inflammatory effects, preserve gut barrier integrity, and modulate the microbiome

But the preclinical evidence is striking enough that major research institutions are investing significant resources to investigate further

Injection site reactions were statistically higher in the albiglutide group (12.9% versus 5.4%, p = 0.0002), possibly due to its once weekly formulation