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Specification and emulation of the reference trial including our expansion studies are stated in the Supplementary Information, following the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline (Supplementary Tables 2729) 42

General eligibility includes: BMI over 30: Individuals who are classified as having obesity

Elucidating the detailed mechanisms of Gq signaling in insulin and GLP-1 secretions may contribute to the development of new treatment strategies for diabetes

doi: 10.1091/mbc.e04-07-0616 42 CoburnCTKnappFFJr.FebbraioMBeetsALSilversteinRLAbumradNA

As Melanie discovered, GLP-1 drugs can help the body in other ways, too

The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]