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The GIP receptor activation enhances fat metabolism and works synergistically with GLP-1 signaling
Additionally, cellular uptake of PEG-ITP-Lip was significantly inhibited in vitro when pretreated with chlorpromazine, suggesting that the ITP-mediated endocytosis pathway is primarily clathrin-dependent (Supplementary Fig

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3.15 Inhibitors of de novo lipogenesis 3.15.1 ACCs inhibitors Acetyl-Coa carboxylases (ACCs) promote de novo lipogenesis through the conversion of Acetyl-CoA to Malonyl-CoA, which is a signaling molecule that suppresses fatty acid oxidation