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Current evidence from large-scale clinical trials and meta-analyses does not establish a causal link between GLP-1-based therapies and increased overall cancer risk in humans

This captures abdominal fat loss better than total body weight

Unlike retatrutide, tirzepatide only binds to 2 hormone receptors, GLP-1 and GIP, and is available with a prescription for weight management and type 2 diabetes

For people with established CVD or multiple CVD risk factors, a GLP-1 RA with proven CV benefit is the first choice to reduce risk of major adverse CV events (MACE) [1, 2]

The burden is highest during weeks 9-24 when both are escalating