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How These Results Compare to Other Weight Loss Medicines Retatrutide's 24.2% mean weight loss at 48 weeks exceeds phase 3 data for semaglutide 2.4 mg (~14.9% at 68 weeks) and is comparable to tirzepatide 15 mg (~22.5% at 72 weeks), though no direct head-to-head trials have been conducted

All individuals were provided lifestyle counseling and randomized (flip of a coin) to receive either Wegovy or a matching placebo (a substance that has no therapeutic effect) for a total of 68 weeks

Development of oral, depot, or transdermal delivery systems may improve adherence