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Many studies have also indicated that alcohol use increases the risk of common diseases, such as cardiovascular disease, liver disease, and cancers, which significantly contribute to mortality and morbidity rates

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Its utility was limited, however, because of an extremely short half-life in humans, but this problem had two solutions, both of which gave rise to important antidiabetic drugs: (1) orally active inhibitors of the enzyme dipeptidylpeptidase 4 (DPP-4 inhibitors), which was responsible for the rapid degradation

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