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Although degradation-resistant GLP-1R agonists have minimal effects on blood vessels (79), they increase HR and reduce cardiac inflammation and infarct size in animals with experimental myocardial infarction (75, 80)

eating smaller portions of high-protein, low-fat foods minimizes gastric distension and reduces chemoreceptor activation

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When a drug is in shortage, federal law under sections 503A and 503B of the Food, Drug and Cosmetic Act permits licensed compounding pharmacies and outsourcing facilities to compound drugs that would otherwise be considered an unapproved copy of an FDA-approved product - an exemption that allowed the compounded GLP-1 telehealth industry to scale significantly between 2022 and 2024

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A JAMA Psychiatry study published in February 2025 showed semaglutide significantly reduced drinking episodes in patients with alcohol use disorder through GLP-1 receptors in the mesolimbic dopamine system that modulate reward processing