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The NTD of GLP-1R is one of its key regions for ligand binding
Cardiovascular and renal outcomes with canagliflozin according to baseline kidney function

10.1056/NEJMoa2108269 30 GoughS
Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al

This epidemiologic shift has prompted renewed interest in systemic prevention strategies that target the biological drivers of colorectal carcinogenesis rather than relying solely on lesion detection
