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Dec 14: High-risk neuroblastoma (HRNB) patients now have an oral maintenance therapy option after the FDA greenlit US WorldMeds Iwilfin (eflornithine)

In vivo preclinical trials results: Comparing sublingual and subcutaneous incretin delivery In vivo preclinical trials Three different healthy pigs were exposed to either a low dose (sublingual 1) or an intermediate dose (sublingual 2) of an incretin or by subcutaneous administration of a standard dose (subcutaneous)

However, spontaneous reporting systems are subject to substantial limitations, including under-reporting, confounding by indication (e.g., diabetes-related xerostomia), channeling bias toward older or more comorbid patients, and polypharmacy involving xerostomia-inducing drugs such as antidepressants and anticholinergics

Additionally, gastrointestinal side effects are most pronounced during the first two weeks at a new dose and typically improve by weeks three and four

Their absence from the label means incidence is unknown, not that the symptom cannot occur