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For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]

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Longitudinal association between medication adherence and glycaemic control in Type 2 diabetes

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doi: 10.2147/CIA.S74042 7 WangXFLinXLiDYZhouRGreenbaumJChenYCet al

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however, this methodology has inherent limitations.182 Furthermore, the guidelines do not differentiate recommendations based on the indication for GLP-1RAs use (eg, diabetes versus obesity) or the specific surgical procedure.74 In cases where patients report gastrointestinal symptoms on the day of surgery, postponement of the procedure is recommended.74 If patients do not adhere to the discontinuation recommendations, the Task Force advises implementing comprehensive gastric protective measures or considering the preoperative assessment of gastric volume via ultrasound

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In contrast, GLP-1 receptor agonists provide a more holistic approach

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Given the continued growth of the obesity epidemic, primary care providers should prescribing GLPs for patients with nondiabetic obesity

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