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GLP-1 medications work partly by influencing the brain circuits involved in set point regulation, which is why they produce larger and more sustained weight loss than dietary approaches

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Further investigation is also needed in specific patient populations

Regulation of Aldosterone Synthesis and Secretion

The primary hurdle for oral GLP-1s has always been the "peptide problem"large molecules are easily broken down in the stomach

The manufacturing challenges also limit the potential for generic competition in the near term, maintaining high costs and access barriers