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Description
In primary mouse chondrocytes, treatment with liraglutide reduced the mRNA expression of iNOS, MMP-13 and ADAMTS5 , thus leading to reduced secretion of a battery of inflammatory markers such as NO, prostaglandin E 2 , and IL-6 [17]
Brown S, Biswas D, Wu J, et al
10.2337/diab.38.7.902 72 KreislerA
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Mechanistically, multi-omics analyses of cardiac and hepatic tissues revealed that semaglutide exerted these benefits by improving cardiac metabolism, interfering with pro-fibrotic and pro-hypertrophic signals, and by reducing systemic inflammation
