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Sweet taste receptor activation in the gut is of limited importance for glucose-stimulated GLP-1 and GIP secretion

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In turn, poor blood sugar control makes gastroparesis worse

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Others are developing medicines that are longer-acting than those from Novo Nordisk and Lilly

Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]