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Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): A 56-week, double-blind, phase 3a, randomised trial

Systematic reviews and meta-analyses of randomized controlled trials have found that GLP-1 receptor agonists significantly decreased CRP levels compared to placebo or other diabetes medications

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Alongside AD, recently the efficacy of daily administration of 40 IU intranasal insulin was evaluated in PD [163]

A vicious cycle unfolds from there: Carrying more weight may pump up the size of your fat cells and trigger inflammation, both of which can make it even tougher for your cells to respond to insulin