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The root cause is systemic insulin resistance, typically driven by high calorie intake and positive energy balance (excess calories)

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Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle

doi: 10.1016/j.bbrc.2009.12.075

Tirzepatide versus semaglutide for weight loss: a meta-analysis of randomized controlled trials

Despite the benefits of GLP-1 receptor agonists, affordability and insurance coverage limitations remain critical barriers in some regions, which could potentially hinder widespread adoption