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Purpose of Review GLP-1 receptor agonists (GLP-1RAs) have become central therapies for obesity and metabolic disease

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Medications in this approach include modulation of peroxisome proliferator-activator receptors (e.g., pemafibrate, elafibranor), medications targeting farnesoid X receptor axis [obeticholic acid

Conclusions GLP-1RA therapy in patients with CS and associated metabolic disorders led to significant improvements in weight, BMI, and glycemic control without worsening cortisol dynamics or liver function

Since semaglutide is expensive, running at around $1000 for a months supply, theres a sizeable population ready to be snared with an offer of a cheaper version