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These drugs work by mimicking the hormone glucagon-like peptide-1 (GLP-1), which regulates appetite, slows gastric emptying, and promotes insulin secretion
(2013) 8:e58445
GLP-1-producing neurons in the NTS project axon terminals widely, densely innervating regions involved in autonomic and metabolic control, such as hypothalamic and thalamic nuclei and the NTS itself (Larsen et al., 1997

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