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Description
Safety Considerations and Who Should Use Compounded GLP-1 Medications Compounded GLP-1 medications carry the same clinical contraindications as branded versions: personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, severe gastrointestinal disease, or active pancreatitis

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The Mounjaro Summary of Product Characteristics notes this effect is most pronounced at initiation and dose increases, and attenuates over time

In cells, it increases expression of canonical ERR target genes and enhances mitochondrial respiration