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Louis show in a new study that GLP-1 medications may be effective at treating and preventing substance use disorders across all major addictive substances studied, suggesting these drugs target a common biological pathway underlying addiction

The biggest risk is diabetic ketoacidosis, especially if insulin doses are reduced too much

Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement

A study published in the Journal of Clinical Endocrinology found that patients with autoimmune thyroiditis had significantly higher HOMA-IR scores (a measure of insulin resistance) than matched controls, regardless of TSH levels

Others are being oversold

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