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In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]

Despite these advances, developing orally effective peptide and protein drugs remains a major scientific challenge and an important focus area in drug delivery research

Briefly, while the extracellular domain (ECD) of GLP-1R, which is responsible for ligand recognition and specificity, engages the C-terminus of the GLP-1, the interhelical transmembrane crevice of the GLP-1R helps in docking of the N-terminus of the GLP-1, triggering downstream signaling ( FIGURE 2 However, the naturally secreted GLP-1 is quickly hydrolyzed and rendered inactive by dipeptidyl peptidase-4 (DPP-4), a transmembrane amino peptidase

This technology may also pave the way for the future development of tablet forms of other peptides, such as insulin," explains Prof