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Discovery of the once-weekly glucagon-like Peptide-1 (GLP-1) analogue Semaglutide

This had been devised as part of an attempt to transplant pancreases into people with severe type 1 diabetes

These agents have a beneficial effect on pancreatic islet function by facilitating the secretion of insulin in response to ambient blood glucose levels and inhibiting glucagon secretion both directly and indirectly

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Reported cases include gastrointestinal symptoms such as nausea, vomiting, diarrhea, belching, and abdominal pain (23)