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This could help distinguish whether the observed increases in gestational weight gain, GDM, and hypertensive disorders reflect a rebound effect after discontinuation versus the underlying metabolic risk profile of the treated population

Specifically, data from tirzepatide discontinuation indicated a BMI rebound of 4.3 units between weeks 36 and 88, translating to 0.083 kg/m 2 /week, 33 which was extrapolated to estimate weight regain after treatment

As per FDA approval in 2021, it's indicated for chronic weight management in adults with obesity or overweight with at least one weight-related condition such as high blood pressure, type 2 diabetes mellitus or high cholesterol (hyperlipidemia)

3 Even small reductions in weight significantly improve outcomes of obesity related chronic diseases

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