does semaglutide affect pancreas Semaglutide as a GLP-1 Agonist:

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Follow-up of participants from the DCCT demonstrated fewer macrovascular and microvascular complications in the group that received intensive treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Caruso I, Di Gioia L, Di Molfetta S, et al

I think the answer lies in a discovery published in Nature in October 2025, a study about how epithelial cells die that inadvertently explained why retatrutide makes some peoples skin hypersensitive

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Individual response varies some patients tolerate retatrutide better than semaglutide and vice versa