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GLP-1 drugs work partly by slowing the stomach and blunting appetite, and during the first weeks and after every dose increase they commonly cause nausea, vomiting, and diarrhea

Available retatrutide body-composition data suggest favorable fat-mass reduction and no obvious disproportionate lean-mass penalty relative to total weight loss

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Clinical data shows that 70% of lost weight typically returns within 12 months after GLP-1 discontinuation without sustained dietary and lifestyle changes

Persistence is further affected by external factors such as cost and access