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Zizzari P, He R, Falk S et al (2021) CB1 and GLP-1 receptors cross talk provides new therapies for obesity

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In the hypothalamus, GLP-1 promotes satiety and reduces hunger signals

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If the pen has already been opened and used, it can stay at room temperature (up to 86F) for up to 56 days, meaning it usually does not need refrigeration during a standard flight