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W przeciwiestwie do konwencjonalnych lekw odchudzajcych lub krtkoterminowych diet, ktre przynosz efekty tylko przez kilka tygodni, GLP-1 bezporednio ingeruje w mechanizm regulacji godu i metabolizmu

Clinical Trials and Research on Retatrutide Retatrutide has been tested for weight loss and weight management in several clinical trials

PMID: 36569429

355:2297-2307 [PubMed: 17135584] 109

GLP-1 receptors are expressed in key reward-related brain regions , including: The ventral tegmental area (VTA) and nucleus accumbens , which form the core of the mesolimbic dopamine pathway The prefrontal cortex , involved in executive function and impulse control The amygdala , which processes emotional salience and stress responses The prevailing hypothesis suggests that GLP-1 receptor activation may modulate dopamine signalling in reward circuits

Higher doses (4.5 mg) were evaluated but discontinued due to excessive gastrointestinal side effects without proportional benefits[7]