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Based on this review, evidence from head-to-head and insulin-comparator trials demonstrates that dual GIP/GLP-1 co-agonism consistently overcomes metabolic plateaus that result from single-pathway therapy, producing superior glycated hemoglobin reduction, bariatric-level weight loss (up to 25.3%), and robust macrovascular and heart failure protection, including a 38% reduction in composite cardiovascular risk among patients with heart failure with preserved ejection fraction (HFpEF)

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I am pleased to see, however, that NICE recognises that some ethnicities may be prone to obesity-related complications at a lower BMI and so have lowered the referral threshold by 2.5kg/m2 for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds

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If you have been feeling unusually tired and unwell in addition to having night sweats for more than 2 weeks, you absolutely need to see a doctor

GLP-1 shots offer a new approach to weight loss management