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If the therapy has been interrupted for a long time, the body is no longer adapted to the physiological changes caused by the medication

Juruena MF, Cleare AJ, Young AH
2012, Dong et al

Hence, we propose a more proactive method to de-insulinization in conjunction with intensive lifestyle adjustment

This approach strengthens the analytical toolkit to going beyond gold-standard techniques like IP-RPLC, enabling efficient tracking of both excipient- and peptide-related CQAs, which help to ensure overall drug product quality

Its chemical formula is C225H348N48O68, a synthetic peptide with 39 amino acids, allowing a single weekly subcutaneous administration due to its long half-life
