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60 YEARS OF POMC: From POMC and -MSH to PAM, molecular oxygen, copper, and vitamin C

Differences in dosing schedules, potency, receptor affinity, and pharmacokinetic profiles help explain these variations in clinical outcomes
Brown, S
2020, pp

Clinical studies evaluating the effect of GLP-1R agonism on neurodegeneration associated with AD are scarce

Because thermoneutrality minimizes the contribution of non-shivering thermogenesis to whole-body energy expenditure and because non-shivering thermogenesis requires functional brown adipose tissue (BAT) [775], these data imply a contribution of endogenous GLP-1R signaling to the control of energy expenditure, at least in diet-induced obese mice, by regulating BAT activity
