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For oral semaglutide , higher doses may also carry risk

Clinical trials show that discontinuing GLP-1 therapy leads to weight regain in approximately 70% of patients within one year, underscoring why these medications function best as long-term treatment rather than temporary interventions

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The findings have raised questions, especially as the number of people using semaglutide medications continues to climb

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Mergenthaler P, Lindauer U, Dienel GA, Meisel A