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However, the significantly greater weight reduction associated with GLP-1 based therapies and their proven health benefits (e.g., reduction in cardiovascular disease with semaglutide [29] and improved sleep apnea with tirzepatide [30]), as well as a wider acceptance that medication is needed for sustained weight reduction success, has triggered a rapid surge in their uptake [31]

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Yancy Among US adults 65 years hospitalized with #HeartFailure with reduced ejection fraction (HFrEF), implementation of quadruple guideline-directed medical therapyangiotensin receptorneprilysin inhibitor, -blocker, mineralocorticoid receptor antagonist, and sodiumglucose cotransporter 2 inhibitorwas projected to reduce hospitalization-related costs by nearly $10 000 annually per patient

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Research suggests that if you havent lost at least 5% of your body weight after 12 to 16 weeks on the full dose, you may be a non-responder

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